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Clin Exp Dermatol. 2007 Jul;32(4):435-8. Epub 2007 Mar 21.

Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients.

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1
Passover Dermatology Centre, Mexico City, Mexico.

Abstract

BACKGROUND:

Chronic discoid lupus erythematosus (CDLE) is present in 15-30% of patients with systemic lupus erythematosus (SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease.

AIM:

The aim of this study was to determine gene frequencies of HLA-DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease.

METHODS:

The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA-DRB1 and DQ allele typing was performed by sequence-specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls.

RESULTS:

In the patient group, a significantly increased gene frequency was found for the HLA-DR4 (P = 0.016, OR = 2.24, 95% CI 1.14-4.38) and HLA-DR16 alleles (P = 0.005, OR = 5.51, 95% CI 1.49-21.08).

CONCLUSION:

HLA-DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.

[Indexed for MEDLINE]

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