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Inorg Chem. 2007 Apr 16;46(8):2944-6. Epub 2007 Mar 22.

Platinum complex as a nanomolar protein kinase inhibitor.

Author information

  • 1Department of Chemistry, University of Pennsylvania, 231 S. 34th Street, Philadelphia, Pennsylvania 19104, USA.

Erratum in

  • Inorg Chem. 2007 May 28;46(11):4758.

Abstract

A pyridocarbazole platinum complex, which matches the overall shape of the natural product staurosporine, binds with high affinity at the adenosine triphosphate binding site of glycogen synthase kinase 3 (GSK-3alpha).

PMID:
17375909
DOI:
10.1021/ic062055t
[PubMed - indexed for MEDLINE]
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