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Cell Mol Life Sci. 2007 Jun;64(12):1471-83.

Purine and pyrimidine receptors.

Author information

1
Autonomic Neuroscience Centre, Royal Free and University College Medical School, London, UK. g.burnstock@ucl.ac.uk

Abstract

Adenosine 5'-triphosphate (ATP), in addition to its intracellular roles, acts as an extracellular signalling molecule via a rich array of receptors, which have been cloned and characterised. P1 receptors are selective for adenosine, a breakdown product of ATP, produced after degradation by ectonucleotidases. Four subtypes have been identified, A(1), A(2A), A(2B) and A(3) receptors. P2 receptors are activated by purines and some subtypes also by pyrimidines. P2X receptors are ligand-gated ion channel receptors and seven subunits have been identified, which form both homomultimers and heteromultimers. P2Y receptors are G protein-coupled receptors, and eight subtypes have been cloned and characterised to date.

PMID:
17375261
DOI:
10.1007/s00018-007-6497-0
[Indexed for MEDLINE]

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