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ACS Chem Biol. 2007 Mar 20;2(3):155-8.

Telomerase unplugged.

Author information

1
Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

Abstract

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

PMID:
17373762
DOI:
10.1021/cb700037c
[Indexed for MEDLINE]

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