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Bioessays. 2007 Apr;29(4):356-70.

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.

Author information

1
Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain. xbustelo@usal.es

Abstract

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family.

PMID:
17373658
PMCID:
PMC1971132
DOI:
10.1002/bies.20558
[Indexed for MEDLINE]
Free PMC Article

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