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Arch Surg. 2007 Mar;142(3):298-303.

Laparoscopically assisted vs open colectomy for colon cancer: a meta-analysis.

Author information

1
Department of Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands. jaap.bonjer@dal.ca

Abstract

OBJECTIVE:

To perform a meta-analysis of trials randomizing patients with colon cancer to laparoscopically assisted or open colectomy to enhance the power in determining whether laparoscopic colectomy for cancer is oncologically safe.

DATA SOURCES:

The databases of the Barcelona, Clinical Outcomes of Surgical Therapy (COST), Colon Cancer Laparoscopic or Open Resection (COLOR), and Conventional vs Laparoscopic-Assisted Surgery in Patients With Colorectal Cancer (CLASICC) trials were the data sources for the study.

STUDY SELECTION:

Patients who had at least 3 years of complete follow-up data were selected.

DATA EXTRACTION:

Patients who had undergone curative surgery before March 1, 2000, were studied. Three-year disease-free survival and overall survival were the primary outcomes of this analysis.

DATA SYNTHESIS:

Of 1765 patients, 229 were excluded, leaving 796 patients in the laparoscopically assisted arm and 740 patients in the open arm for analysis. Three-year disease-free survival rates in the laparoscopically assisted and open arms were 75.8% and 75.3%, respectively (95% confidence interval [CI] of the difference, -5% to 4%). The associated common hazard ratio (laparoscopically assisted vs open surgery with adjustment for sex, age, and stage) was 0.99 (95% CI, 0.80-1.22; P = .92). The 3-year overall survival rate after laparoscopic surgery was 82.2% and after open surgery was 83.5% (95% CI of the difference, -3% to 5%). The associated hazard ratio was 1.07 (95% CI, 0.83-1.37; P = .61). Disease-free and overall survival rates for stages I, II, and III evaluated separately did not differ between the 2 treatments.

CONCLUSION:

Laparoscopically assisted colectomy for cancer is oncologically safe.

PMID:
17372057
DOI:
10.1001/archsurg.142.3.298
[Indexed for MEDLINE]

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