Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Soc Trans. 2007 Apr;35(Pt 2):416-20.

The APP family of proteins: similarities and differences.

Author information

1
Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Republic of Ireland. dominic.walsh@ucd.ie

Abstract

Overwhelming evidence indicates that the Abeta (amyloid beta-peptide) plays a critical role in the pathogenesis of Alzheimer's disease. Abeta is derived from the APP (amyloid precursor protein) by the action of two aspartyl proteases (beta- and gamma-secretases) that are leading candidates for therapeutic intervention. APP is a member of a multigene family that includes APLP1 (amyloid precursor-like protein 1) and APLP2. Both APLPs are processed in a manner analogous to APP, with all three proteins subject to ectodomain shedding and subsequent cleavage by gamma-secretase. Careful study of the APP family of proteins has already revealed important insights about APP. Here, we will review how knowledge of the similarities and differences between APP and the APLPs may prove useful for the development of novel disease-modifying therapeutics.

PMID:
17371289
DOI:
10.1042/BST0350416
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center