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Biochem Soc Trans. 2007 Apr;35(Pt 2):245-9.

Chemically targeting the PI3K family.

Author information

1
Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA, USA.

Abstract

PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain for efforts to pharmacologically target the PI3K family.

PMID:
17371250
DOI:
10.1042/BST0350245
[Indexed for MEDLINE]

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