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Genes Dev. 2007 Mar 15;21(6):649-54.

A novel checkpoint mechanism regulating the G1/S transition.

Author information

1
Department of Cell Biology, Rikshospitalet-Radiumhospitalet Medical Centre and University of Oslo, Montebello, 0310 Oslo, Norway.

Erratum in

  • Genes Dev. 2007 May 15;21(10):1273.

Abstract

Ultraviolet irradiation of fission yeast cells in G1 phase induced a delay in chromatin binding of replication initiation factors and, consistently, a transient delay in S-phase entry. The cell cycle delay was totally dependent on the Gcn2 kinase, a sensor of the nutritional status, and was accompanied by phosphorylation of the translation initiation factor eIF2alpha and by a general depression of translation. However, the G1-specific synthesis of factors required for DNA replication was not reduced by ultraviolet radiation. The cell cycle delay represents a novel checkpoint with a novel mechanism of action that is not activated by ionizing radiation.

PMID:
17369398
PMCID:
PMC1820939
DOI:
10.1101/gad.421807
[Indexed for MEDLINE]
Free PMC Article

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