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Sleep Med. 2007 Apr;8(3):260-5. Epub 2007 Mar 21.

Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.

Author information

1
University of Minnesota, Department of Veterinary and Biomedical Sciences, Rm 295, Animal Science/Veterinary Medicine Building, 1988 Fitch Avenue, St. Paul, MN 55113, USA.

Abstract

BACKGROUND:

The hypothalamic neuropeptide hypocretin (orexin) modulates sleep-wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy-cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities.

METHODS:

We determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence.

RESULTS:

Basal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls.

CONCLUSIONS:

These findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.

PMID:
17369087
DOI:
10.1016/j.sleep.2006.08.015
[Indexed for MEDLINE]

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