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Hum Pathol. 2007 Apr;38(4):527-36.

Pathological effects of drugs on the gastrointestinal tract: a review.

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1
Department of Pathology, London Health Sciences Centre and University of Western Ontario, London, Ontario, Canada.

Abstract

Drug-induced injury of the gastrointestinal (GI) tract is increasingly common but generally under-recognized. Although there is an overwhelming number of drugs that are associated with adverse GI effects, there is a limited number of characteristic injury patterns that should prompt consideration of drug-induced GI pathology. These include the following: erosions, ulcers, and strictures; crystal deposition; parietal cell changes; reactive gastropathy; pseudodysplastic changes; microscopic colitis; infectious or necrotizing enterocolitis; ischemic colitis; focal active colitis; and increased epithelial apoptosis. This article reviews morphological and pathophysiological features of some of the more common and pathologically recognizable drug-related injury patterns and provides a practical guide for the recognition and diagnosis of drug-induced pathology in the upper and lower GI tract.

PMID:
17367604
DOI:
10.1016/j.humpath.2007.01.014
[Indexed for MEDLINE]
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