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Pacing Clin Electrophysiol. 2007 Mar;30(3):371-6.

Chronic renal insufficiency is an independent predictor of mortality in implantable cardioverter-defibrillator recipients.

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VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48105, USA.



Chronic renal insufficiency (CRI) has been associated with increased risk of cardiovascular morbidity and mortality. However, there is limited knowledge regarding this association and the effect of renal dysfunction on survival benefit in patients with implantable cardioverter-defibrillators (ICDs).


We investigated whether there was an association between CRI (defined as serum creatinine levels >or=1.5 mg/dL) and increased risk of mortality in ICD recipients. We retrospectively studied all patients (n = 336) followed within our ICD clinic in a 2.5-year period. CRI, ventricular tachycardia (VT), cardiomyopathy (CM), and mortality were recorded. Ischemic CM was defined as the presence of coronary artery disease (CAD) and left ventricular ejection fraction <or= 30%.


Despite no significant difference in CAD and VT occurrence between CRI and non-CRI groups in the overall population, there was a significantly higher mortality rate in the CRI group (P < 0.0001).


CRI is a significant independent predictor of mortality in ICD recipients. Further investigation is needed to determine whether prevention, early detection, and more aggressive intervention in the treatment of CRI will reduce the incidence of mortality in this population.

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