Format

Send to

Choose Destination
J Environ Sci Health B. 2007 Feb;42(2):151-5.

Assessment of oxidative stress due to exposure to pesticides in plasma and urine of traditional limited-resource farm workers: formation of the DNA-adduct 8-hydroxy-2-deoxy-guanosine (8-OHdG).

Author information

1
Nutrition and Health Program, Kentucky State University, Frankfort, Kentucky 40601, USA. avinash.tope@kysu.edu

Abstract

The objective of this study was to assess the risk of genotoxicity caused due to oxidative stress using plasma and urinary levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) in farm workers for six months during a growing season. Blood and urine samples were collected once a month for six months (June to November 2003) from farm workers (n = 15) and urban unexposed controls (n = 10). Plasma and urinary levels of 8-OHdG were evaluated by Enzyme Linked Immunosorbent Assay (ELISA) technique. There was no significant difference in the urinary levels of 8-OHdG between the farm workers and the control group, but there was an approximately four-fold increase in mean values of plasma 8-OHdG levels in the farm worker group (P < or = 0.05).

PMID:
17365329
DOI:
10.1080/03601230601123276
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center