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J Cardiovasc Magn Reson. 2007;9(3):549-56.

A combined method for the determination of myocardial perfusion in experimental animals using microspheres and CMR.

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1
The Department of Biochemistry, Molecular Genetics University of Alabama, Birmingham, Alabama 35294-0005, USA.

Abstract

A convenient method is introduced for myocardial perfusion research by combining multislice short-axis cine cardiovascular magnetic resonance (MSA-CMR) and colored microspheres (CM). In canine control-ischemia-reperfusion (n = 11), Cardiac output (CO) was measured using MSA-CMR (COMSA), Phase Contrast CMR (PC-CMR, COPC) and CM (from reference blood samples, COmicro) in 3 experimental periods per animal. COmicro significantly and systematically overestimated COMSA (median deviation: 291 mL/min, p < 0.01), while there was excellent agreement between PC-CMR and MSA-CMR without significant over-or underestimation (median deviation: -14 ml/min, p = NS). In quantitative myocardial perfusion assay by CM, CMR should be used instead of reference blood sampling. This should improve the accuracy of absolute regional perfusion measurement.

PMID:
17365234
DOI:
10.1080/10976640601015177
[Indexed for MEDLINE]
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