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J Asthma. 2007 Jan-Feb;44(1):35-8.

Comparison of Delta FVC (% decrease in FVC at the PC(20)) between cough-variant asthma and classic asthma.

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Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea.


The percentage decrease in forced vital capacity (FVC) at the methacholine PC(20) (Delta FVC) has been proposed as a surrogate marker of maximal airway response. The aim of this study was to compare the Delta FVC between patients with cough-variant asthma (CVA) and those with classic asthma (CA). We performed a retrospective analysis of methacholine challenge test data from 47 children who were diagnosed as having CVA and from 75 children who had CA of mild severity. The mean (+/- SD) Delta FVC was significantly (p = 0.001) lower in the CVA group (14.7 +/- 3.4%) compared with the CA group (17.1 +/- 4.4%), whereas PC(20) was not different between the two groups. Our results suggest that CVA is associated with a lower level of maximal airway response than CA.

[Indexed for MEDLINE]

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