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Crit Rev Biotechnol. 2007 Jan-Mar;27(1):1-19.

Microbial biosynthesis of polyglutamic acid biopolymer and applications in the biopharmaceutical, biomedical and food industries.

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1
Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.

Abstract

This review article provides an updated critical literature review on the production and applications of Polyglutamic Acid (PGA). alpha-PGA is synthesized chemically, whereas gamma-PGA can be produced by a number of microbial species, most prominently various Bacilli. Great insight into the microbial formation of gamma-PGA has been gained thanks to the development of molecular biological techniques. Moreover, there is a great variety of applications for both isoforms of PGA, many of which have not been discovered until recently. These applications include: wastewater treatment, food products, drug delivery, medical adhesives, vaccines, PGA nanoparticles for on-site drug release in cancer chemotherapy, and tissue engineering.

PMID:
17364686
DOI:
10.1080/07388550601166458
[Indexed for MEDLINE]
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