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J Clin Immunol. 2007 Jul;27(4):347-62. Epub 2007 Mar 16.

Host innate immune response to Mycobacterium tuberculosis.

Author information

1
Department of Medicine, Centre for Emerging Pathogens, UMDNJ-New Jersey Medical School, Newark, New Jersey 07101, USA.

Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

PMID:
17364232
DOI:
10.1007/s10875-007-9084-0
[Indexed for MEDLINE]

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