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World J Urol. 2007 Mar;25(1):3-9. Epub 2007 Feb 14.

Overdiagnosis and overtreatment of early detected prostate cancer.

Author information

1
Department of Urology, Erasmus University Medical Centre, PO Box 2040, 3000 DR Rotterdam, Netherlands. h.j.vanalphen@erasmusmc.nl

Abstract

Early detection of prostate cancer is associated with the diagnosis of a considerable proportion of cancers that are indolent, and that will hardly ever become symptomatic during lifetime. Such overdiagnosis should be avoided in all forms of screening because of potential adverse psychological and somatic side effects. The main threat of overdiagnosis is overtreatment of indolent disease. Men with prostate cancer that is likely to be indolent may be offered active surveillance. Evaluation of active surveillance studies and validation of new biological parameters for risk assessment are expected.

PMID:
17364211
PMCID:
PMC1913182
DOI:
10.1007/s00345-007-0145-z
[Indexed for MEDLINE]
Free PMC Article

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