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Science. 1992 Jan 31;255(5044):603-6.

The Son of sevenless gene product: a putative activator of Ras.

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  • 1Department of Biology, University of California, Los Angeles 90024.


The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.

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