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Ann N Y Acad Sci. 2007 Sep;1111:275-89. Epub 2007 Mar 15.

Characteristics of the protective subcellular coccidioidal T27K vaccine.

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Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA.


While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.

[Indexed for MEDLINE]

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