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Ann N Y Acad Sci. 2007 Sep;1111:275-89. Epub 2007 Mar 15.

Characteristics of the protective subcellular coccidioidal T27K vaccine.

Author information

1
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA. smjohnson@ucdavis.edu

Abstract

While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.

PMID:
17363436
DOI:
10.1196/annals.1406.016
[Indexed for MEDLINE]

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