Format

Send to

Choose Destination
See comment in PubMed Commons below
Math Biosci. 2007 Sep;209(1):30-50. Epub 2007 Feb 8.

Travelling gradients in interacting morphogen systems.

Author information

1
Centre for Mathematical Biology, Mathematical Institute, University of Oxford, 24-29 St. Giles', Oxford OX1 3LB, UK. ruth.baker@maths.ox.ac.uk

Abstract

Morphogen gradients are well known to play several important roles in development; however the mechanisms underlying the formation and maintenance of these gradients are often not well understood. In this work, we investigate whether the presence of a secondary morphogen can increase the robustness of the primary morphogen gradient to perturbation, thereby providing a more stable mechanism for development. We base our model around the interactions of Fibroblast Growth Factor 8 and retinoic acid, which have been shown to act as morphogens in many developmental systems. In particular, we investigate the formation of opposing gradients of these morphogens along the antero-posterior axis of vertebrate embryos, thereby controlling temporal and spatial aspects of axis segmentation and neuronal differentiation.

PMID:
17363011
DOI:
10.1016/j.mbs.2007.01.006
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center