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Am J Otolaryngol. 2007 Mar-Apr;28(2):78-82.

Moxifloxacin vs amoxicillin/clavulanate in the treatment of acute sinusitis.

Author information

1
Hospital General Dr. Manuel Gea González, Mexico City, Mexico.

Abstract

PURPOSE:

The aim of this study was to compare the efficacy and safety of moxifloxacin with that of amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults.

MATERIALS AND METHODS:

Five hundred seventy-five patients from Latin American countries were randomized to receive oral moxifloxacin 400 mg once daily for 7 days, or oral amoxicillin/clavulanate 500/125 mg 3 times daily for 10 days, in a prospective, open study.

RESULTS:

At the test-of-cure visit (7-14 days after the end of therapy), the clinical success rate in the moxifloxacin group was 93.4% similar to that in the amoxicillin/clavulanate group (92.7%). Documented bacteriological eradication plus presumed eradication rates in the moxifloxacin (96.5%) and the amoxicillin/clavulanate (96.7%) groups were also similar. Drug-related adverse events were recorded in 32.2% of patients in the moxifloxacin group and 29.7% in the amoxicillin/clavulanate group. Patient discontinuation in the trial due to adverse events occurred for 10 patients in the moxifloxacin group and 6 in the amoxicillin/clavulanate group.

CONCLUSIONS:

Overall, in terms of clinical and bacteriological response, moxifloxacin was equivalent to amoxicillin/clavulanate for the treatment of acute bacterial sinusitis in adults.

PMID:
17362810
DOI:
10.1016/j.amjoto.2006.06.016
[Indexed for MEDLINE]

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