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Int J Clin Pract. 2007 Jul;61(7):1223-9. Epub 2007 Mar 16.

The change in zoster-associated pain treated with oral valaciclovir in immunocompetent patients with acute herpes zoster.

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Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.


We have analysed zoster-associated pain treated with valaciclovir (VCV) in immunocompetent patients with acute herpes zoster over 6 months, and evaluated the safety of VCV. We know of no reports that evaluate postherpetic neuralgia (PHN) treated with VCV for 6 months. Predisposing factors that influence PHN were age (over 60 years), clustered vesicles, severity of eruption, sleep disturbance, and hypesthesia. Timing of the administration of VCV before or after the onset of rash did not influence the incidence of PHN. No serious adverse reactions were observed during the administration of VCV.

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