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Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3973-7. Epub 2007 Feb 28.

Innate response to self-antigen significantly exacerbates burn wound depth.

Author information

1
Harvard Medical School, Boston, MA 02115, USA.

Abstract

A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.

PMID:
17360462
PMCID:
PMC1820693
DOI:
10.1073/pnas.0609026104
[Indexed for MEDLINE]
Free PMC Article

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