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Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1185-93.

The peptide pheromone-inducible conjugation system of Enterococcus faecalis plasmid pCF10: cell-cell signalling, gene transfer, complexity and evolution.

Author information

1
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA. dunny001@umn.edu

Abstract

Expression of a large set of gene products required for conjugative transfer of the antibiotic resistance plasmid pCF10 is controlled by cell-cell communication between plasmid-free recipient cells and plasmid-carrying donor cells using a peptide mating pheromone cCF10. Most of the recent experimental analysis of this system has focused on the molecular events involved in initiation of the pheromone response in the donor cells, and on the mechanisms by which the donor cells control self-induction by endogenously produced pheromone. Recently, studies of the molecular machinery of conjugation encoded by the pheromone-inducible genes have been initiated. In addition, the system may serve as a useful bacterial model for addressing the evolution of biological complexity.

PMID:
17360276
PMCID:
PMC2435581
DOI:
10.1098/rstb.2007.2043
[Indexed for MEDLINE]
Free PMC Article
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