Format

Send to

Choose Destination
See comment in PubMed Commons below
In Vivo. 2007 Jan-Feb;21(1):89-92.

The effect of aspartame administration on oncogene and suppressor gene expressions.

Author information

  • 1Faculty of Medicine, Institute of Public Health University of Pécs, Pécs, Hungary. katalin_gombos@yahoo.com

Erratum in

  • In Vivo. 2007 Nov-Dec;21(6):1172.

Abstract

BACKGROUND:

Aspartame (L-phenylalanine N-L-alpha-aspartyl-1-methyl ester) is an artificial sweetener with widespread applications. Previously published results have shown that among rats receiving aspartame a significant increase of lymphoreticular neoplasms, brain tumours and transitional cell tumours occurred. The aim of our short-term experiment was to investigate the biological effect of aspartame consumption by determining the expressions of key oncogenes and a tumour suppressor gene.

MATERIALS AND METHODS:

After one week per os administration of various doses of aspartame to CBA/CA female mice, p53, c-myc, Ha-ras gene expression alterations were determined in individual organs.

RESULTS:

The results showed an increase in gene expressions concerning all the investigated genes especially in organs with a high proliferation rate: lymphoreticular organs, bone-marrow and kidney.

CONCLUSION:

Aspartame has a biological effect even at the recommended daily maximum dose.

PMID:
17354619
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center