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Eur J Biochem. 1992 Feb 1;203(3):499-503.

Localization of a vitamin-D-binding protein interaction site in the COOH-terminal sequence of actin.

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UPR 8402 Centre de Recherche de Biochimie Macromoléculaire CNRS, U249 INSERM, Laboratoire de Motilité Cellulaire, Université de Montpellier I, France.


The serum vitamin D binding protein is the carrier of vitamin D and its derivatives in the plasma. One of the known roles of this protein is to sequester monomeric actin in the blood, therefore implicating this protein in actin elimination. However, its binding site at the surface of actin is poorly delimited. We report here the results of a study which locates, using several actin fragments together with immunological probes, a vitamin D binding protein site near the COOH-terminal extremity. Thus, the interface is delimited by the sequence 360-372 in subdomain I of actin.

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