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Planta Med. 2007 Mar;73(3):292-5. Epub 2007 Mar 12.

Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa.

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1
Centro de Ciências e Humanidades, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil.

Abstract

Bioactivity-guided fractionation of the alkaloidal fractions of the CH2Cl2 extract from branches of Porcelia macrocarpa using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of bioactive alkaloids: two tetrahydrobenzylisoquinolines (1 and 2), two aporphines (3 and 4), one proaporphine (5), one oxoaporphine (6), four azantraquinones (7-10) and four azafluorenones (11-14). The alkaloids cleistopholine (7) and 6-methoxycleistopholine (8) showed the highest fungitoxic activity while the mixture of 6- and 7-methoxyonychine (12+13) and 6,7-dimethoxyonychine (14) showed a weak DNA-damaging potential.

PMID:
17354171
DOI:
10.1055/s-2007-967108
[Indexed for MEDLINE]
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