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Curr Opin Obstet Gynecol. 2007 Apr;19(2):113-9.

Reproductive outcomes after in-vitro fertilization.

Author information

1
St. Georges Hospital, University of London, London, United Kingdom. n.m@doctors.org.uk

Abstract

PURPOSE OF REVIEW:

This paper reviews the effect of in-vitro fertilization on maternal and perinatal outcomes of pregnancy.

RECENT FINDINGS:

Few randomized, controlled trials have been published in this area due to inherent difficulties in studying this population of infertile women who require in-vitro fertilization. Systematic review of the literature identified published studies that consistently highlighted the higher incidence of maternal and perinatal morbidity associated with pregnancies following in-vitro fertilization.

SUMMARY:

Some prospective observational studies compare maternal and perinatal outcomes in in-vitro fertilization pregnancies. Larger studies show that adverse pregnancy outcomes such as preeclampsia, gestational hypertension, placental abruption, placenta praevia, and preterm delivery increase significantly with in-vitro fertilization. Perinatal adverse outcomes such as prematurity and those related to plurality of the pregnancy also increase. All patients undergoing in-vitro fertilization should have careful counselling regarding these increased risks prior to treatment.

PMID:
17353678
DOI:
10.1097/GCO.0b013e32807fb199
[Indexed for MEDLINE]

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