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Nat Neurosci. 2007 Apr;10(4):414-6. Epub 2007 Mar 11.

Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala.

Author information

1
Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication (NAMC), Centre National de la Recherche Scientifique (CNRS), UMR8620, Université Paris-Sud, 91405 Orsay, France.

Abstract

When reactivated, memories enter a labile, protein synthesis-dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted synapses.

PMID:
17351634
DOI:
10.1038/nn1871
[Indexed for MEDLINE]

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