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Nat Struct Mol Biol. 2007 Apr;14(4):341-3. Epub 2007 Mar 11.

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

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1
Howard Hughes Medical Institute, USA.

Abstract

Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

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PMID:
17351631
DOI:
10.1038/nsmb1216
[Indexed for MEDLINE]
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