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Mutat Res. 2007 May 1;618(1-2):30-40. Epub 2007 Jan 21.

The Chd family of chromatin remodelers.

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1
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Abstract

Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent chromatin remodelers. The Chd proteins are distinguished by the presence of two N-terminal chromodomains that function as interaction surfaces for a variety of chromatin components. Genetic, biochemical, and structural studies demonstrate that Chd proteins are important regulators of transcription and play critical roles during developmental processes. Numerous Chd proteins are also implicated in human disease.

PMID:
17350655
PMCID:
PMC1899158
DOI:
10.1016/j.mrfmmm.2006.07.012
[Indexed for MEDLINE]
Free PMC Article
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