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Mol Cell Neurosci. 2007 Apr;34(4):679-88. Epub 2007 Feb 2.

Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse.

Author information

1
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA; Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.

Abstract

Odorant receptor (OR) genes can be classified into two types: fish-like class I OR genes and mammalian-specific class II OR genes. We have previously shown that Lhx2, a LIM-homeodomain protein, binds to the homeodomain site in the promoter region of mouse M71, a class II OR, and that a knockout mutation in Lhx2 precludes expression of all tested class II OR genes including M71. Here, we report that most class I OR genes, which are expressed in a dorsal region of the olfactory epithelium, are still expressed in Lhx2-deficient embryos. There are two exceptions: two class I OR genes, which are normally expressed in a more ventral region, are no longer expressed in Lhx2 mutant mice. Lhx2 is transcribed in olfactory sensory neurons irrespective of expression of class I or class II OR genes. Thus, a deficiency of Lhx2 has a differential impact on class I and class II OR gene expression.

PMID:
17350283
DOI:
10.1016/j.mcn.2007.01.014
[Indexed for MEDLINE]

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