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Bioorg Med Chem Lett. 2007 May 15;17(10):2838-43. Epub 2007 Feb 25.

Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.

Author information

1
Endocrinology Unit, Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. scott.webster@ed.ac.uk

Abstract

A series of adamantyl amide 11beta-HSD1 inhibitors has been discovered and chemically modified. Selected compounds are selective for 11beta-HSD1 over 11beta-HSD2 and possess excellent cellular potency in human and murine 11beta-HSD1 assays. Good pharmacodynamic characteristics are observed in ex vivo assays.

PMID:
17350260
DOI:
10.1016/j.bmcl.2007.02.057
[Indexed for MEDLINE]

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