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Trends Biochem Sci. 2007 Apr;32(4):165-71. Epub 2007 Mar 8.

Contending with transcriptional arrest during RNAPII transcript elongation.

Author information

1
Clare Hall Laboratories, Cancer Research UK London Research Institute, South Mimms, London EN6 3LD, UK. j.svejstrup@cancer.org.uk

Abstract

Studies of RNA polymerase II (RNAPII) transcript elongation have revealed an extremely complex biochemical process. Obstacles to transcription, such as nucleosomes and DNA damage, must be overcome constantly, requiring the involvement of numerous accessory factors with diverse functions. Together, these factors ensure that transcript elongation is, overall, a highly efficient reaction. The understanding of the basic biochemical principles and factors underlying transcript elongation by RNAPII has greatly improved over the past few years. In particular, studies of RNAPII ubiquitylation and degradation have provided new insight into how cells handle obstacle-induced transcriptional arrest.

PMID:
17349792
DOI:
10.1016/j.tibs.2007.02.005
[Indexed for MEDLINE]
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