Format

Send to

Choose Destination
Cancer Cell. 2007 Mar;11(3):214-6.

A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. tonks@cshl.edu

Abstract

The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.

PMID:
17349579
DOI:
10.1016/j.ccr.2007.02.022
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center