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J Pain Symptom Manage. 2007 Mar;33(3):356-64.

Multimodal approaches to the management of neuropathic pain: the role of topical analgesia.

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1
Department of Anesthesiology and Critical Care Medicine, Roswell Park Cancer Institute, School of Medicine and Biomedical Studies, State University of New York at Buffalo, Buffalo, New York 14263, USA. oscar.deleon@roswellpark.org

Abstract

Because of their localized activity and low systemic absorption, topical analgesics have a favorable safety profile and a low risk for drug-drug interactions. There is a growing body of evidence on the efficacy and safety of these agents in a variety of pain disorders, including the most prevalent neuropathic pain conditions. The molecular basis for the usage of peripheral analgesics in neuropathic pain and the available clinical trial evidence for a wide variety of topical agents are reviewed.

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