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Cell Mol Immunol. 2007 Feb;4(1):31-41.

Nuclear factor-kappaB: activation and regulation during toll-like receptor signaling.

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1
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. rcarmody@mail.med.upenn.edu

Abstract

Toll-like receptors (TLRs) recognize distinct microbial components to initiate the innate and adaptive immune responses. TLR activation culminates in the expression of appropriate pro-inflammatory and immunomodulatory factors to meet pathogenic challenges. The transcription factor NF-kappaB is the master regulator of all TLR-induced responses and its activation is the pivotal event in TLR-mediated activation of the innate immune response. Many of the key molecular events required for TLR-induced NF-kappaB activation have been elucidated. However, much remains to be learned about the ability of TLRs to generate pathogen-specific responses using a limited number of transcription factors. This review will focus on our current understanding of NF-kappaB activation by TLRs and potential mechanisms for achieving a signal-specific response through NF-kappaB.

PMID:
17349209
[Indexed for MEDLINE]
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