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Phytomedicine. 2007 Apr;14(4):289-300. Epub 2007 Mar 7.

Acetylcholinesterase inhibitors from plants.

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1
Department of Pharmacy, Pharmacognosy Research Laboratories, Franklin-Wilkins Building, King's College London, 150 Stamford Street, London SE1 9NH, UK. pulokm@gmail.com

Abstract

Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity. Numerous phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.

PMID:
17346955
DOI:
10.1016/j.phymed.2007.02.002
[Indexed for MEDLINE]
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