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Cell Microbiol. 2007 Apr;9(4):817-28. Epub 2007 Mar 8.

Phagocytosis and persistence of Helicobacter pylori.

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Inflammation Program and the Department of Medicine, University of Iowa and the VA Medical Center, Iowa City, IA 52242, USA.


Helicobacter pylori is a spiral-shaped, flagellated, microaerophilic Gram-negative bacterium that colonizes the gastric epithelium of humans. All persons infected with H. pylori have gastritis, and some will develop severe disease such as peptic ulcers or gastric cancer. A characteristic feature of this infection is the pronounced accumulation of phagocytes, particularly neutrophils, in the gastric mucosa. H. pylori thrives in a phagocyte-rich environment, and we describe here how this organism uses an array of novel virulence factors to manipulate chemotaxis, phagocytosis, membrane trafficking and the respiratory burst as a means to evade elimination by the innate immune response.

[Indexed for MEDLINE]

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