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Kidney Int. 2007 Mar;71(6):477-9.

Renal response to repeated exposure to endotoxin: implications for acute kidney injury.

Author information

1
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. nath.karl@mayo.edu

Abstract

Zager and colleagues demonstrate that endotoxin tolerance is accompanied by an augmented inflammatory response in the kidney, the latter also exhibiting cholesterol-dependent cytoresistance. These novel findings are discussed mainly from the perspective of acute kidney injury and its prevention by preconditioning and the elicitation of cytoprotective pathways.

PMID:
17344894
DOI:
10.1038/sj.ki.5002150
[Indexed for MEDLINE]
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