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Bioinformatics. 2007 Jul 15;23(14):1815-23. Epub 2007 Mar 7.

EuSplice: a unified resource for the analysis of splice signals and alternative splicing in eukaryotic genes.

Author information

1
Department of Human Genetics, Genome Technologies, Inc., 8000 Excelsior Drive, Madison, WI 53717, USA.

Abstract

MOTIVATION:

Despite increased availability of genome annotation data, a comprehensive resource for in-depth analysis of splice signal distributions and alternative splicing (AS) patterns in eukaryote genomes is still lacking. To meet this need, we have developed EuSplice--a unique splice-centric database which provides reliable splice signal and AS information for 23 eukaryotes.

RESULTS:

The EuSplice database contains 95,822 AS events and 2.1 million splice signals associated with over 270,000 protein-coding genes. The intuitive, user-friendly EuSplice web interface has powerful data mining and graphics capabilities for inter-genomic comparative analysis of splice signals, putative cryptic splice sites and AS events. Moreover, the seamless integration of splicing data to extensive gene-specific annotations, such as homolog annotations, functional information, mutations and sequence details makes EuSplice a powerful one-stop information resource for investigating the molecular mechanisms of complex splicing events, disease associations and the evolution of splicing in eukaryotes.

AVAILABILITY:

http://66.170.16.154/EuSplice.

SUPPLEMENTARY INFORMATION:

Supplementary tables and figures at Bioinfo online.

PMID:
17344236
DOI:
10.1093/bioinformatics/btm084
[Indexed for MEDLINE]
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