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Development. 2007 Apr;134(8):1455-63. Epub 2007 Mar 7.

Foxe view of lens development and disease.

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  • 1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.


The recent identification of a mutation in Foxe3 that causes congenital primary aphakia in humans marks an important milestone. Congenital primary aphakia is a rare developmental disease in which the lens does not form. Previously, Foxe3 had been shown to play a crucial role in vertebrate lens formation and this gene is one of the earliest integrators of several signaling pathways that cooperate to form a lens. In this review, we highlight recent advances that have led to a better understanding of the developmental processes and gene regulatory networks involved in lens development and disease.

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