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Blood Cells Mol Dis. 2007 May-Jun;38(3):258-68. Epub 2007 Mar 6.

Vascular endothelial growth factor family of ligands and receptors: review.

Author information

1
Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut-Medical Center, Beirut 1107 2802, Lebanon.

Abstract

VEGF signaling often represents a critical rate-limiting step in physiological angiogenesis. The VEGF family comprises seven secreted glycoproteins that are designated VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, placental growth factor (PlGF) and VEGF-F. The VEGF family members bind their cognate receptors. The receptors identified so far are designated VEGFR-1, VEGFR-2, VEGFR-3 and the neuropilins (NP-1 and NP-2). We review in this article the biology of the VEGF ligands and the receptors.

PMID:
17344076
DOI:
10.1016/j.bcmd.2006.12.003
[Indexed for MEDLINE]

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