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Life Sci. 1992;50(6):PL31-3.

MK801 antagonism of the prolonged depletion of striatal dopamine by amphetamine in iprindole-treated rats.

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Eli Lilly and Company, Lilly Corporate Center, Indianapolis, In 46285.


The administration of amphetamine to rats pretreated with iprindole to inhibit the metabolism of amphetamine results in a long-lasting depletion of striatal dopamine and its metabolites, DOPAC and HVA. Pretreatment with MK801, a noncompetitive antagonist of the NMDA (N-methyl-D-aspartate) subclass of excitatory amino acid receptors, antagonized the depletion of striatal dopamine, DOPAC and HVA 3 days after a single dose of amphetamine in iprindole-treated rats. MK801 pretreatment was effective up to 4 hours but not at 8 or 24 hours in preventing amphetamine effects on striatal dopamine, DOPAC and HVA.

[Indexed for MEDLINE]

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