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Planta Med. 1985 Feb;51(1):50-2.

Assay methods for antihepatotoxic activity using peroxide-induced cytotoxicity in primary cultured hepatocytes1.

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1
Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan.

Abstract

Conditions were investigated to devise IN VITRO assay methods for antihepatotoxic activity using peroxide-induced damage in primary cultured rat liver cells. Utilizing linoleic acid peroxide, benzoyl peroxide, cumene hydroperoxide and adenosine diphosphate/Fe (3+), satisfactory assay procedures were established. Some natural products known to exert liver-protective effects IN VIVO were screened to reveal that glycyrrhetinic acid, glycyrrhizin, cynarin, silybin and desoxypodophyllotoxin showed similar antihepatotoxic activity in these four assay methods.

PMID:
17340401
DOI:
10.1055/s-2007-969391

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