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Planta Med. 1984 Feb;50(1):78-80.

Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul.

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1
Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India.

Abstract

A ketosteroid has been isolated from the oleo-resin of COMMIPHORA MUKUL and its structure (4,17(20)trans pregnandiene 3,16-dione; Z-guggulsterone) established from its physico-chemical properties, specially UV, IR, NMR and mass-spectra. The isolated ketosteroid showed a strong thyroid stimulatory action when administered to albino rats. Its administration (1 mg/100 g body weight) brought about an increase in iodine-uptake by thyroid and enhanced activities of thyroid peroxidase and protease as well as oxygen consumption by isolated slices of liver and biceps muscle.

PMID:
17340256
DOI:
10.1055/s-2007-969626

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