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Genetics. 2007 May;176(1):703-9. Epub 2007 Mar 4.

The Caenorhabditis elegans Rad17 homolog HPR-17 is required for telomere replication.

Author information

1
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599-3280, USA.

Abstract

Subunits of the Rad9/Rad1/Hus1 (9-1-1) proliferating cell nuclear antigen (PNCA)-like sliding clamp are required for DNA damage responses and telomerase-mediated telomere replication in the nematode Caenorhabditis elegans. PCNA sliding clamps are loaded onto DNA by a replication factor C (RFC) clamp loader. The C. elegans Rad17 RFC clamp loader homolog, hpr-17, functions in the same pathway as the 9-1-1 complex with regard to both the DNA damage response and telomerase-mediated telomere elongation. Thus, hpr-17 defines an RFC-like complex that facilitates telomerase activity in vivo in C. elegans.

PMID:
17339221
PMCID:
PMC1893056
DOI:
10.1534/genetics.106.070201
[Indexed for MEDLINE]
Free PMC Article

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