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Clin Chest Med. 2007 Mar;28(1):143-67, ix.

The nitric oxide/cGMP signaling pathway in pulmonary hypertension.

Author information

1
Division of Pulmonary Sleep and Critical Care Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. james_klinger@brown.edu

Abstract

This article briefly reviews the background of endothelium-dependent vasorelaxation, describes the nitric oxide/cGMP/protein kinase pathway and its role in modulating pulmonary vascular tone and remodeling, and describes three approaches that target the nitric oxide/cGMP pathway in the treatment of patients with pulmonary arterial hypertension.

PMID:
17338933
DOI:
10.1016/j.ccm.2006.12.002
[Indexed for MEDLINE]

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