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Immunol Res. 2006;36(1-3):247-54.

Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles.

Author information

1
Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Abstract

Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.

PMID:
17337785
DOI:
10.1385/IR:36:1:247
[Indexed for MEDLINE]

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